Nicomp 380 Instrument Options
 

Autodilution or Flow Thru Cell

This patented option eliminates the need for manual dilution of concentrated sample.  Autodilution makes particle size analysis quick and easy, with no training required.  Results are highly reproducible.

High Power Laser Diodes

An array of high power laser diodes are available to meet the needs of the most demanding applications.  Higher power lasers are required to extend the lower limit of the instrument by providing adequate scattering from small particles.  These are also useful when measuring particles such as dextrans, which yield insufficient scattering intensity because of index of refraction properties.  Microemulsions, surfactant micelles, proteins and other macroemulsions can also be measured using HPLD’s.  The extent of aggregation of biopolymers after reconstitution without chromatographic separation is also possible.

Avalanche Photo Diode (APD) Detectors

The Nicomp 3080 may be equipped with various high-powered lasers as well as a high-gain APD which provides approximately seven times the gain of a conventional photomultiplier tube.  The APS is used to increase the signal-to-noise and sensitivity in systems that do not scatter light well.  Proteins, micelles, other macro-molecular based systems, and nanoparticles are often dilute (1 mg/ml or less) and are made of atoms that do not scatter light well.  The APD coupled with a nominally higher power laser diode module offers a low cost solution for accurately analyzing nanoparticles in a short period of time.

Channel Photomulitplier Detector (CPM)

A high gain detector that has approximately four times the sensitivity of a standard PMT.  It also has a very robust design that allows it to be exposed to high levels of light.  This makes it ideal for applications where a wide variety of samples will be analyzed.

Multi-angle

Particles larger than 200nm do not scatter light isotropically in all directions.  It is possible to make DLS measurements more sensitive to certain sized particles by changing the angle of detection.  The 7030 can be equipped with a mini-goniometer that in a range from 12- 175 degrees incrementally moves the optical fiber by 0.9 degrees. 

Autosampler

Batch sampling may be performed by adding a 27-sample autosampler module when increased efficiency is paramount.

Zeta Potential

Electrophoretic Light Scattering is the method by which zeta potential of charged particles in liquid suspension is measured in the Nicomp 3080 ZLS.  A small aliquot of sample is placed in a disposable cuvette and palladium electrodes are then inserted.  The entire cell is placed into the Nicomp 3080.  Because of the unique design there is no need to align the cell to the stationary plane.  Once the cell is placed a simple slick of the mouse starts the measurement.

Low Volume Analysis

Analysis available in an indexed matched cell down to 40mL.

Particle Sizing Systems, 2009
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